FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\UBQLN1UAS.cHa
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General Information
Symbol
Hsap\UBQLN1UAS.cHa
Species
H. sapiens
Name
Saccharomyces cerevisiae UAS construct a of Hanson
FlyBase ID
FBal0294177
Feature type
allele
Associated gene
Hsap\UBQLN1
Associated Insertion(s)
Carried in Construct
P{UAS-UBQLN1.H}
Key Links
Transgenic product class
wild_type
(Hanson et al., 2010)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Hanson et al., 2010)
Mutagen
in vitro construct
(Hanson et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-UBQLN1.H}
Cytology
Description

UASt regulatory sequences drive expression of wild-type Hsap\UBQLN1.

(Hanson et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\UBQLN1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  amyotrophic lateral sclerosis
      modeled by Hsap\TARDBPUAS.cHa
      (Hanson et al., 2010)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\UBQLN1Scer\UAS.cHa in motor neurons under the control of Scer\GAL4D42 extends Drosophila lifespan.

      (Hanson et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Enhancer of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Flies co-expressing Hsap\UBQLN1Scer\UAS.cHa and Hsap\TARDBPScer\UAS.cHa both under the control of Scer\GAL4D42 show reduced survival as compared with Scer\GAL4D42>Hsap\TARDBPScer\UAS.cHa flies.

      Flies co-expressing Hsap\UBQLN1Scer\UAS.cHa and Hsap\TARDBPScer\UAS.cHa both under the control of Scer\GAL4D42 have higher rates of wing malformation than the respected single Hsap\TARDBPScer\UAS.cHa-transgenic line.

      (Hanson et al., 2010)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\UBQLN1Scer\UAS.cHa
      Hsap\UBQLN1UAS.cHa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Hanson
      Secondary FlyBase IDs
        References (1)