FlyBase Allele Report: Dmel\Bsg[HMC03195]

General Information

Symbol

Dmel\Bsg^HMC03195

Species

D. melanogaster

Name

FlyBase ID

FBal0294289

Feature type

allele

Associated gene

Dmel\Bsg

Associated Insertion(s)

Carried in Construct

P{TRiP.HMC03195}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMC03195}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMC03195

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | larval stage, with Scer\GAL4^hh.PU

(Alizzi et al., 2020)

abnormal neuroanatomy | larval stage, with Scer\GAL4^ppk.PG

(Alizzi et al., 2020)

increased cell number | pupal stage, with Scer\GAL4^fkh.PH

(Velentzas et al., 2018)

Phenotype Manifest In

dendritic branch | larval stage, with Scer\GAL4^hh.PU

(Alizzi et al., 2020)

dendritic branch | larval stage, with Scer\GAL4^ppk.PG

(Alizzi et al., 2020)

dendritic tree | larval stage, with Scer\GAL4^hh.PU

(Alizzi et al., 2020)

dendritic tree | larval stage, with Scer\GAL4^ppk.PG

(Alizzi et al., 2020)

larval multidendritic class IV neuron | larval stage, with Scer\GAL4^hh.PU

(Alizzi et al., 2020)

larval multidendritic class IV neuron | larval stage, with Scer\GAL4^ppk.PG

(Alizzi et al., 2020)

microtubule | larval stage, with Scer\GAL4^ppk.PG

(Alizzi et al., 2020)

salivary gland | pupal stage, with Scer\GAL4^fkh.PH

(Velentzas et al., 2018)

Detailed Description

Statement

Reference

In individuals expressing Bsg^HMC03195 under the control of Scer\GAL4^ppk.PG or Scer\GAL4^hh.PU, L3 class IV da neurons show loss of dendritic field coverage. Arbors show a decrease in stable microtubules compared to controls.

(Alizzi et al., 2020)

Expressing Bsg^HMC03195 under the control of Scer\GAL4^fkh.PH leads to a significant proportion of individuals with some persisting salivary gland tissue 24h after puparium formation, i.e. 8hr after the time when this tissue is usually cleared in control individuals.

(Velentzas et al., 2018)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Bsg^HMC03195, Scer\GAL4^ppk.PG has abnormal neuroanatomy | larval stage phenotype, non-enhanceable by fne^UAS.cCa, Scer\GAL4^ppk.PG

(Alizzi et al., 2020)

NOT suppressed by