FB2026_02 , released June 18, 2026
Allele: Dmel\twin41
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General Information
Symbol
Dmel\twin41
Species
D. melanogaster
Name
FlyBase ID
FBal0295024
Feature type
allele
Associated gene
Dmel\twin
Associated Insertion(s)
P{3'wHy}twin41
Carried in Construct
Key Links
Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Joly et al., 2013)
Mutagen
hobo activity
(Joly et al., 2013)
Progenitor genotype
P{wHy}twinDG24102
(Joly et al., 2013)
Associated Insertion(s)
P{3'wHy}twin41
Cytology
Description

Mobilisation of the hobo element in the P{wHy}twinDG24102 insertion, resulting in loss of part of the P{wHy} element.

(Joly et al., 2013)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      100% of germaria lack germline stem cells (GSCs) in the ovaries of 7 day old twin41/Df(3R)Exel6198 females.

      (Joly et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The germarium phenotype of bamΔ86 Df(3R)Exel6198/twin41 bamΔ86 double mutant females is a mixture of a bam mutant phenotype (accumulation of germline stem cell (GSC)-like cells containing a spectrosome) and a twin mutant phenotype (lack of GSCs or lack of germ cells). The phenotype changes over time, with the percentage of bam mutant phenotype decreasing and the percentage of twin mutant phenotype increasing as the flies age. The double mutant GSCs are able to differentiate.

      (Joly et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      twin41
      (Joly et al., 2013)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)