FlyBase Allele Report: Dmel\Ibf2[GSV17]

General Information

Symbol

Dmel\Ibf2^GSV17

Species

D. melanogaster

Name

FlyBase ID

FBal0295808

Feature type

allele

Associated gene

Dmel\Ibf2

Associated Insertion(s)

P{?GSV6}Ibf2^GSV17

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Cuartero et al., 2014)

Mutagen

P-element activity

(Cuartero et al., 2014)

Progenitor genotype

P{GSV6}Ibf2^GS16482

(Cuartero et al., 2014)

Associated Insertion(s)

P{?GSV6}Ibf2^GSV17

Cytology

Description

Mobilization of P{GSV6}Ibf2^GS16482, resulting in loss of the w gene from the transposon sequences but retention of part of the transposon that renders the Ibf2 gene nonfunctional.

(Cuartero et al., 2014)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

homeotic (with Df(3R)ED5339)

(Cuartero et al., 2014)

homeotic | dominant

(Cuartero et al., 2014)

male sterile

(Cuartero et al., 2014)

male sterile (with Df(3R)ED5339)

(Cuartero et al., 2014)

partially lethal - majority live

(Cuartero et al., 2014)

partially lethal - majority live (with Df(3R)ED5339)

(Cuartero et al., 2014)

short lived

(Cuartero et al., 2014)

short lived (with Df(3R)ED5339)

(Cuartero et al., 2014)

Phenotype Manifest In

abdominal sternite 7 | female limited

(Cuartero et al., 2014)

abdominal sternite 7 | female limited (with Df(3R)ED5339)

(Cuartero et al., 2014)

Detailed Description

Statement

Reference

Homozygotes and hemizygotes with Df(3R)ED5339 show reduced viability (60-70%), male sterility and many of the eclosed flies are short-lived.

70% of Ibf2^GSV17 homozygous adult females exhibit loss of bristle formation in the A7 sternite - bristles resemble those normally found in more anterior sternites. 14% of Ibf2^GSV17 heterozygotes and 72% of Ibf2^GSV17/Df(3R)ED5339 transheterozygotes also show this phenotype.

(Cuartero et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygosity for Ibf2^GSV17 increases the eye pigmentation in w^+mC.Fab-8 flies (in a w[-] background). Homozygosity for Ibf2^GSV17 increases eye pigmentation still further.

(Cuartero et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Ibf2^GSV17 behaves as a double Ibf1, Ibf2 null mutation regarding chromatin regulation, as Ibf1 protein is unable to bing chromatin in the absence of Ibf2.

(Cuartero et al., 2014)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Ibf2^GSV17

(Cuartero et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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