FB2026_02 , released June 18, 2026
Allele: Dmel\SelRC124S.UAS
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General Information
Symbol
Dmel\SelRC124S.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0296074
Feature type
allele
Associated gene
Dmel\SelR
Associated Insertion(s)
Carried in Construct
P{UAS-SelR.C124S}
Also Known As
UAS:SelRC124S
Key Links
Genomic Maps

Transgenic product class
missense_variant
(Hung et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Hung et al., 2013)
Mutagen
in vitro construct
(Hung et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-SelR.C124S}
Cytology
Description

UASt regulates expression of SelR containing a C124S mutation of the critical catalytic cysteine to generate an enzymatically dead protein.

(Hung et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
SelR
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:10,863,733..10,863,733 [-]
Nucleotide change:

T10863733A

Reported nucleotide change:

T?A

Amino acid change:

C124S | SelR-PA; C135S | SelR-PB; C166S | SelR-PC; C177S | SelR-PE; C124S | SelR-PI

Reported amino acid change:

C124S

Comment:

In transgenic construct. Creates enzymatically dead version of the protein.

(Hung et al., 2013)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of SelRC124S.Scer\UAS under the control of Scer\GAL4B11-98 results in branched bristles.

      (Hung et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressed by
      Enhancer of
      Statement
      Reference

      SelRC124S.UAS, Scer\GAL4B11-98 is an enhancer of macrochaeta phenotype of MicalUAS.s, Scer\GAL4B11-98

      (Hung et al., 2013)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of SelRC124S.Scer\UAS enhances the branched bristle phenotype seen upon Scer\GAL4B11-98-mediated expression of MicalScer\UAS.s, increasing both number and length of branches. Addition of Act5CM44L.Scer\UAS.T:Avic\GFP into this background abrogates the effect of SelRC124S.Scer\UAS.

      (Hung et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      SelRC124S.Scer\UAS
      SelRC124S.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (2)