FB2026_03 , released September 17, 2026
Allele: Dmel\Vps16AFUD
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General Information
Symbol
Dmel\Vps16AFUD
Species
D. melanogaster
Name
FlyBase ID
FBal0296356
Feature type
allele
Associated gene
Dmel\Vps16A
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Takáts et al., 2014)
Mutagen
spontaneous
(Takáts et al., 2014)
Progenitor genotype
Cytology
Description

The last three nucleotides of the third intron of Vps16A have been mutated from CAG to GAG.

(Takáts et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:9,267,807..9,267,807 [+]
Nucleotide change:

C9267807G

Comment:

CAG to GAG mutaton at the 3' end of the 3rd intron is thought to interfere with splicing.

(Takáts et al., 2014)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Autolysosome formation is inhibited in the fat body cells of starved Vps16AFUD mutant wandering third instar larvae. The cytoplasm of these cells is filled with typical double-membrane autophagosomes.

      Autolysosome formation is inhibited in the fat body cells of starved Vps16AFUD/Df(3R)ED5339 mutant wandering third instar larvae.

      (Takáts et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Separable from: P{lacW}l(3)S007902S007902

      (Takáts et al., 2014)

      The lethality and autophagosome defects seen in Vps16AFUD are separable from the P{lacW}l(3)S007902S007902 insertion.

      (Takáts et al., 2014)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      Vps16AFUD
      Vps16A[FUD]
      (Takáts et al., 2014)
      l(3)S007902(FUD)
      (Takáts et al., 2014)
      Name Synonyms
      Fusion Defective
      (Takáts et al., 2014)
      Secondary FlyBase IDs
        References (1)