FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\dop10
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General Information
Symbol
Dmel\dop10
Species
D. melanogaster
Name
FlyBase ID
FBal0296385
Feature type
allele
Associated gene
Dmel\dop
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Hain et al., 2014)
Mutagen
ethyl methanesulfonate
(Hain et al., 2014)
Progenitor genotype
Cytology
Description

Amino acid replacement: R524term.

(Hain et al., 2014)

The premature stop codon is within the DUF domain.

(Hain et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:15,570,385..15,570,385 [+]
Nucleotide change:

C15570385T

Amino acid change:

R524term | dop-PA; R524term | dop-PB

Reported amino acid change:

R524term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Hain et al., 2014)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Mutants are female sterile, embryonic lethal and produce membrane growth defects in cellularization. Adults show variable wing and leg defects.

      (Hain et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      dop10/Df(3L)MR15 is partially rescued by dopUASp.Tag:HA/Scer\GAL4VP16.mat.αTub67C

      (Hain et al., 2014)

      dop10/Df(3L)MR15 is partially rescued by dopΔPDZ.UASp/Scer\GAL4VP16.mat.αTub67C

      (Hain et al., 2014)

      dop10/Df(3L)MR15 is partially rescued by dopΔDUF.UASp/Scer\GAL4VP16.mat.αTub67C

      (Hain et al., 2014)
      Not rescued by

      dop10/Df(3L)MR15 is not rescued by Scer\GAL4VP16.mat.αTub67C/dopΔKin.UASp

      (Hain et al., 2014)
      Comments

      Scer\GAL4mat.αTub67C.T:Hsim\VP16-mediated expression of dopScer\UAS.T:Ivir\HA1 rescues the lethality of dop10/Df(3L)MR15 in over 60% of mutant embryos.

      Scer\GAL4mat.αTub67C.T:Hsim\VP16-mediated expression of dopΔPDZ.Scer\UAS or dopΔDUF.Scer\UAS rescues the lethality of dop10/Df(3L)MR15 at a low level.

      Scer\GAL4mat.αTub67C.T:Hsim\VP16-mediated expression of dopΔDUF.Scer\UAS does not rescue the lethality of dop10/Df(3L)MR15.

      (Hain et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      dop10
      (Hain et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)