FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Als2Ex44
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General Information
Symbol
Dmel\Als2Ex44
Species
D. melanogaster
Name
FlyBase ID
FBal0296462
Feature type
allele
Associated gene
Dmel\Als2
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Takayama et al., 2014)
Progenitor genotype
P{EP}Als2G4607
(Takayama et al., 2014)
Cytology
Description

Imprecise excision of the P{EP}Als2G4607 progenitor insertion, resulting in a 1453bp deletion that removes part of Als2. Part of the original insertion remains.

(Takayama et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:21,678,168..21,679,620 [-]
Comment:

Inferred boundaries of a 1453 bp deletion resulting from the imprecise excision of P{EP}Als2G4607 which removes part of Als2. Part of the original insertion remains.

(Takayama et al., 2014)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  amyotrophic lateral sclerosis
      CEA
      (Takayama et al., 2014)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygotes are viable and fertile and adults appear morphologically normal.

      Number of boutons per muscle area at the neuromuscular junction (NMJ) is not significantly different from wild type in homozygous third instar larvae and muscle size appears normal.

      In 2 week old homozygous adults, presynaptic arbor area and normalised bouton number at the NMJ is not significantly different from wild type, but the absolute value of bouton number per terminal is increased.

      Homozygotes show an age-dependent decline in climbing ability compared to age-matched controls.

      (Takayama et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Als2Ex44 is rescued by Scer\GAL4Ubi.PU/Als2UAS.Tag:HA

      (Takayama et al., 2014)
      Comments

      Expression of Als2Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Ubi rescues the reduced climbing ability of 2 week old Als2Ex44 homozygotes.

      (Takayama et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Als2Ex44
      Ex44
      (Takayama et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)