FlyBase Allele Report: Dmel\ATP8B[ll2]

General Information

Symbol

Dmel\ATP8B^ll2

Species

D. melanogaster

Name

FlyBase ID

FBal0296606

Feature type

allele

Associated gene

Dmel\ATP8B

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Liu et al., 2014)

Mutagen

ethyl methanesulfonate

(Liu et al., 2014)

Progenitor genotype

Cytology

Description

Nonsense mutation (C to T at genomic location 3R:7 ,902,447) in the first coding exon common to all predicted isoforms of ATP8B, and is thus predicted to severely truncate all encoded proteins.

(Liu et al., 2014)

Nucleotide substitution: C?T.

(Liu et al., 2014)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:12,076,725..12,076,725 [-]

Nucleotide change:

C12076725T

Reported nucleotide change:

C7902447T

Amino acid change:

Reported amino acid change:

??term

Comment:

C to T mutation reported at 3R:7902447 in genome release 5 coordinates.

(Liu et al., 2014)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neurophysiology

(Liu et al., 2014)

abnormal neurophysiology (with ATP8B^f05203)

(Liu et al., 2014)

abnormal neurophysiology (with Df(3R)Exel7312)

(Liu et al., 2014)

abnormal neurophysiology (with Df(3R)Exel8155)

(Liu et al., 2014)

abnormal smell perception

(Liu et al., 2014)

abnormal smell perception (with ATP8B^f05203)

(Liu et al., 2014)

abnormal smell perception (with Df(3R)Exel7312)

(Liu et al., 2014)

abnormal smell perception (with Df(3R)Exel8155)

(Liu et al., 2014)

viable

(Liu et al., 2014)

Phenotype Manifest In

Detailed Description

Statement

Reference

ATP8B^ll2 homozygous, or ATP8B^ll2/Df(3R)Exel7312, ATP8B^ll2/Df(3R)Exel8155 or ATP8B^ll2/ATP8B^f05203 trans-heterozygous flies show a reduced electroantennogram response to most tested odorants known to excite a variety of different ORN classes. The response to CO[[2]] is unaffected however. Neurons on the maxillary palp show an equivalent reduction in ATP8B^ll2 homozygotes.

(Liu et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

From the Zuker Collection.

(Liu et al., 2014)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ATP8B^ll2

dATP8B^ll2

(Liu et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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