FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\PsaUAS.cKa
Open Close
General Information
Symbol
Dmel\PsaUAS.cKa
Species
D. melanogaster
Name
FlyBase ID
FBal0297911
Feature type
allele
Associated gene
Dmel\Psa
Associated Insertion(s)
Carried in Construct
P{UAS-Psa.K}
Key Links
Transgenic product class
wild_type
(Kruppa et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Kruppa et al., 2013)
Mutagen
in vitro construct
(Kruppa et al., 2013)
Progenitor genotype
Carried in construct
P{UAS-Psa.K}
Cytology
Description

UASt regulatory sequences drive expression of Psa coding sequences.

(Kruppa et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Psa
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of PsaScer\UAS.cKa under the control of Scer\GAL4elav-C155 results in a mild reduction in longevity.

      (Kruppa et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of PsaScer\UAS.cKa results in an increase in median survival in flies expressing Hsap\APPArctic.Aβ42.Scer\UAS.cJa.T:SS-nec under the control of Scer\GAL4elav-C155. In addition, PsaScer\UAS.cKa expression suppresses the retinal toxicity associated with Hsap\APPArctic.Aβ42.Scer\UAS.cJa.T:SS-nec expression, resulting in normal eye development. These flies are also functionally protected, as shown by improved locomotor function throughout their adult life, as compared to flies expressing Hsap\APPArctic.Aβ42.Scer\UAS.cJa.T:SS-nec alone. Coexpression of PsaScer\UAS.cKa results in a marked reduction in the number of AΒ deposits.

      (Kruppa et al., 2013)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      PsaScer\UAS.cKa
      PsaUAS.cKa
      Name Synonyms
      Secondary FlyBase IDs
        References (1)