FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mh2
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General Information
Symbol
Dmel\mh2
Species
D. melanogaster
Name
FlyBase ID
FBal0299127
Feature type
allele
Associated gene
Dmel\mh
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Delabaere et al., 2014)
Mutagen
P-element activity
(Delabaere et al., 2014)
Progenitor genotype
mhKG05829
(Delabaere et al., 2014)
Cytology
Description

Imprecise excision of P{SUPor-P}mhKG05829 resulting in a 903bp deletion in mh which generates a premature STOP codon at the end of the second exon, leaving only 65 residues of the 724 aa predicted wild type protein.

(Delabaere et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
X:15,474,158..15,475,060 [-]
Comment:

Inferred boundaries of a 903 bp deletion resulting from the imprecise excision of P{SUPor-P}mhKG05829 which retains only 65aa of the wild type amino acid sequence.

(Delabaere et al., 2014)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous mh2 females produce eggs in normal quantities, but that fail to hatch. Hemizygous mh2/Y males are viable and fertile. Fertilization, pronuclear decondensation and apposition seem to occur normally in mh2 eggs. However, in metaphase of the first zygotic mitosis, paternal chromosomes appear improperly condensed and systematically form a chromatin bridge in anaphase. Most mh2 embryos arrest their development after a few catastrophic mitoses, but about 20% escape this early arrest and develop as nonviable gynogenetic haploid embryos after the loss of paternal chromosomes at the first mitosis.

      Paternal chromosomes can at least initiate replication in eggs derived from homozygous mh2 females.

      Mutant third instar larvae exposed to UV radiation show reduced survival to adulthood compared to controls.

      (Delabaere et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      mh2 is rescued by mhUAS.Bac

      (Delabaere et al., 2014)

      mh2 is rescued by mhTag:V5

      (Delabaere et al., 2014)
      Partially rescued by

      mh2 is partially rescued by mhC699STOP.Tag:V5

      (Delabaere et al., 2014)

      mh2 is partially rescued by mhΔSHP.Tag:V5

      (Delabaere et al., 2014)

      mh2 is partially rescued by mhΔPIP.Tag:V5

      (Delabaere et al., 2014)
      Not rescued by

      mh2 is not rescued by mhHVMIH.Tag:V5

      (Delabaere et al., 2014)

      mh2 is not rescued by mhLEMIA.Tag:V5

      (Delabaere et al., 2014)

      mh2 is not rescued by mhC588F.Tag:V5

      (Delabaere et al., 2014)

      mh2 is not rescued by mhΔUBZ.Tag:V5

      (Delabaere et al., 2014)
      Comments

      mhT:SV5\V5 and mhScer\UAS.Bac rescue the female sterility of mh2.

      mhT:SV5\V5 rescues the UV radiation sensitivity of mh2.

      The female sterility of mh2 is partially rescued by mhC699STOP.T:SV5\V5, mhΔSHP.T:SV5\V5 or mhΔPIP.T:SV5\V5, but is not rescued by mhHVMIH.T:SV5\V5, mhLEMIA.T:SV5\V5, mhC588F.T:SV5\V5 or mhΔUBZ.T:SV5\V5.

      (Delabaere et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      mh2
      (Delabaere et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)