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General Information
Symbol
Dmel\SxlM8
Species
D. melanogaster
Name
FlyBase ID
FBal0299614
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Comment:

that eliminates bases +9212 through +9321 relative to the transcription start site of the Sxl "maintenance" promoter, taking out both of the 3' splice sites of the male-specific Sxl exon, as well as the polypyrimidine tract that those splice sites depend on.

Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

110bp deletion that eliminates bases +9212 through +9321 relative to the transcription start site of the "maintenance" promoter, taking out both of the 3' splice sites of the male-specific Sxl exon, as well as the polypyrimidine tract that those splice sites depend on. Consequently, the fully female pre-mRNA Sxl splicing pattern occurs by default in this allele, regardless of X chromosome dose, and the gene is fully constitutive from the moment that the "establishment" promoter is active.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference
External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

SxlM8 is a fully constitutive Sxl allele whose constitutive character cannot be modified by mutations in other genes that affect pre-mRNA splicing.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (3)