FlyBase Allele Report: Dmel\inv[Δ24]

General Information

Symbol

Dmel\inv^Δ24

Species

D. melanogaster

Name

FlyBase ID

FBal0299739

Feature type

allele

Associated gene

Dmel\inv

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

FLPase

Nature of the Allele

Allele class

Mutagen

FLPase

(Cheng et al., 2014)

Progenitor genotype

Cytology

Description

A 24.0kb deletion at the inv locus ( 2R:7357207-7381178 , genome release v5).

(Cheng et al., 2014)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2R:11,469,702..11,493,673 [+]

Comment:

Scer\FRT-mediated recombination between two progenitor insertions has resulted in the deletion of the genomic sequence between them.

(Cheng et al., 2014)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

fertile

(Cheng et al., 2014)

viable

(Cheng et al., 2014)

Phenotype Manifest In

Detailed Description

Statement

Reference

inv^Δ24 mutant adults do not show any obvious morphological defects.

(De et al., 2016)

inv^Δ24 mutant homozygotes are viable, fertile and look phenotypically normal.

(Cheng et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

inv[+]/inv^Δ24 is an enhancer of visible | adult stage phenotype of en^Δ1.5

(De et al., 2016)

Other

Statement

Reference

Df(2R)Δ110, inv^Δ24 has visible | adult stage phenotype

(De et al., 2016)

en^Δ1.5, inv[+]/inv^Δ24 has visible | adult stage phenotype

(De et al., 2016)

Df(2R)Δ110/+, en^Δ1.5, inv[+]/inv^Δ24 has visible | adult stage phenotype

(De et al., 2016)

Phenotype Manifest In

Enhancer of

Statement

Reference

inv[+]/inv^Δ24 is an enhancer of adult abdomen phenotype of en^Δ1.5

(De et al., 2016)

Other

Statement

Reference

Df(2R)Δ110, inv^Δ24 has wing phenotype

(De et al., 2016)

Df(2R)Δ110, inv^Δ24 has wing vein phenotype

(De et al., 2016)

en^Δ1.5, inv[+]/inv^Δ24 has wing phenotype

(De et al., 2016)

en^Δ1.5, inv[+]/inv^Δ24 has posterior crossvein phenotype

(De et al., 2016)

Df(2R)Δ110/+, en^Δ1.5, inv[+]/inv^Δ24 has wing vein phenotype

(De et al., 2016)

Df(2R)Δ110/+, en^Δ1.5, inv[+]/inv^Δ24 has adult abdomen phenotype

(De et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Majority of inv^Δ24/Df(2R)Δ110 flies display wing posture defects (held-out wings) and about 16% also show wing vein abnormalities.

en^Δ1.5 homozygous mutants carrying one copy of inv^Δ24 show wing posture defects (held-out wings), extra wing vein material at the posterior crossvein and the penetrance of abdominal hemisegments fusion defects observed in en^Δ1.5-only mutants is increased to 100%.

en^Δ1.5 heterozygotes homozygous for inv^Δ24 show fully penetrant hemisegment fusion phenotype but only about 14% percent of them also display aberrant wing posture. The full double homozygotes all hold-out their wings in addition to the fusion defects and also exhibit an ectopic wing vein material phenotype of similar severity and penetrance as the en^Δ1.5,inv^Δ24/en^Δ1.5,+ flies.

en^Δ1.5,inv^Δ24/Df(2R)Δ110 adults show fully penetrant wing posture, wing vein as well as hemisegment fusion defects.

(De et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

inv^Δ24

(De et al., 2016, Cheng et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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