FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\PAPLA1Δ1682-1686
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General Information
Symbol
Dmel\PAPLA1Δ1682-1686
Species
D. melanogaster
Name
FlyBase ID
FBal0299769
Feature type
allele
Associated gene
Dmel\PAPLA1
Associated Insertion(s)
Carried in Construct
P{PAPLA1.ΔGHSLG}
Key Links
Genomic Maps

Transgenic product class
inframe_deletion
(Kunduri et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Kunduri et al., 2014)
Mutagen
in vitro construct
(Kunduri et al., 2014)
Progenitor genotype
Carried in construct
P{PAPLA1.ΔGHSLG}
Cytology
Description

A 31-kb genomic fragment modified to carry an active site mutation in PAPLA1. The residues corresponding to the sequence GHSLG at 1682-1686 in the PAPLA1 polypeptide are deleted.

(Kunduri et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
PAPLA1
Encoded product / tool
PAPLA1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2L:8,135,740..8,135,754 [-]
Comment:

Deletion of 5 amino acids (GHSLG) in the enzyme active site created on 31 kb PAPLA1 rescue genomic fragment by site-directed mutagenesis.

(Kunduri et al., 2014)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      PAPLA1Δ1682-1686 fails to rescue PAPLA1KO

      (Kunduri et al., 2014)
      Comments

      Transgenic lines encoding PAPLA1Δ1682-1686 fail to rescue the male sterile phenotype of PAPLA1KO.

      (Kunduri et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      PAPLA1Δ1682-1686
      Name Synonyms
      Secondary FlyBase IDs
        References (1)