FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\slpr::Tak1TSK.UASp.Tag:HA
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General Information
Symbol
Dmel\slpr::Tak1TSK.UASp.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0301276
Feature type
allele
Associated gene
slpr::Tak1
Associated Insertion(s)
Carried in Construct
P{UASp-TSK-HA}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Stronach et al., 2014)
Progenitor genotype
Carried in construct
P{UASp-TSK-HA}
Cytology
Description

UASp regulatory sequences drive expression of full length Tak1 in which the kinase domain has been replaced with the kinase domain from slpr. The chimeric protein consists of amino acids 1-18 of Tak1, followed by amino acids 128-385 of slpr and 272-678 of Tak1. The construct is tagged at the C-terminal end with two copies of Tag:HA.

(Stronach et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
slpr::Tak1
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      slpr::Tak1TSK.UASp.Tag:HA/Scer\GAL4da.G32 is a non-suppressor of abnormal immune response phenotype of Tak12

      (Stronach et al., 2014)
      Phenotype Manifest In
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      slpr::Tak1TSK.UASp.Tag:HA/Scer\GAL4arm.PS is a non-suppressor of embryo | dorsal closure stage phenotype of slpr921

      (Stronach et al., 2014)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of slpr::Tak1TSK.Scer\UAS.P\T.T:Ivir\HA1 under the control of Scer\GAL4arm.PS further enhances the lethality associated with slprBS06 mutant males.

      Expression of slpr::Tak1TSK.Scer\UAS.P\T.T:Ivir\HA1 under the control of Scer\GAL4arm.PS does not rescue the dorsal closure phenotype seen in slpr921 mutant males. Some embryos exhibit head defects.

      Expression of slpr::Tak1TSK.Scer\UAS.P\T.T:Ivir\HA1 suppresses the reduction in eye size seen when egrGS9830 is expressed under the control of Scer\GAL4GMR.PF.

      Expression of slpr::Tak1TSK.Scer\UAS.P\T.T:Ivir\HA1 under the control of Scer\GAL4da.G32 does not suppress the increased susceptibility to E.coli challenge seen in Tak12/Y males. Expression of slpr::Tak1TSK.Scer\UAS.P\T.T:Ivir\HA1 does not increase susceptibility of Tak12/+ females to E.coli.

      (Stronach et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      slpr::Tak1TSK.Scer\UAS.P\T.T:Ivir\HA1
      slpr::Tak1TSK.UASp.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (1)