FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\grkhs.RNAi
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General Information
Symbol
Dmel\grkhs.RNAi
Species
D. melanogaster
Name
FlyBase ID
FBal0301417
Feature type
allele
Associated gene
Dmel\grk
Associated Insertion(s)
Carried in Construct
P{hs-grk.RNAi}
Key Links
Transgenic product class
RNAi_reagent
(Niepielko and Yakoby, 2014)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Niepielko and Yakoby, 2014)
Mutagen
in vitro construct
(Niepielko and Yakoby, 2014)
Progenitor genotype
Carried in construct
P{hs-grk.RNAi}
Cytology
Description

Heat-shock promoter sequences drive expression of grk cDNA sequences arranged in an inverted hairpin loop.

(Niepielko and Yakoby, 2014)
Allele components
Component
Use(s)
Encoded product / tool
grk
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Heat-shock induced expression of grkhs.dsRNA results in defects in embryonic dorsal appendage formation. Approximately 5% exhibit severe defects, 68% are fused, and 27% are wild-type. Over 70% of these heat-shocked flies have some level of disrupted eggshells. Flies kept at 18[o]C exhibit mostly wild-type eggshells.

      (Niepielko and Yakoby, 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      grkhs.RNAi
      grkhs.dsRNA
      Name Synonyms
      Secondary FlyBase IDs
        References (2)