FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\NavΔ-2
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General Information
Symbol
Dmel\NavΔ-2
Species
D. melanogaster
Name
FlyBase ID
FBal0301619
Feature type
allele
Associated gene
Dmel\Nav
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Abe et al., 2014)
Mutagen
FLPase
(Abe et al., 2014)
Progenitor genotype
PBac{RB}Nave02238
(Abe et al., 2014)
PBac{WH}Navf06833
(Abe et al., 2014)
Caused by aberration
Df(2L)NavΔ-2
Cytology
Description

The 520 amino acids corresponding to the third proline-rich region and the first CC motif of sick have been deleted. The non-coding genes CR43828 and CR43827 are also deleted.

(Abe et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2L:19,914,490..19,929,731 [+]
Comment:

Scer\FRT-mediated recombination between the two progenitor insertions has resulted in the deletion of the genomic sequence between them.

(Abe et al., 2014)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      sickΔ-2/Df(2L)ED1303 mutant mushroom bodies display short α/β axonal lobes compared with those of controls.

      No α/β axonal lobe phenotypes are observed in the mushroom bodies of sickΔ-2/+ mutants.

      sickΔ/sickΔ-2 mutant mushroom bodies display short α/β axonal lobes compared with those of controls.

      (Abe et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      NavΔ-2
      sickΔ-2
      (Abe et al., 2014)
      Name Synonyms
      sickieΔ-2
      (Abe et al., 2014)
      Secondary FlyBase IDs
        References (1)