FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\NAT1ex1
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General Information
Symbol
Dmel\NAT1ex1
Species
D. melanogaster
Name
FlyBase ID
FBal0302232
Feature type
allele
Associated gene
Dmel\NAT1
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Yoshikane et al., 2007)
Mutagen
P-element activity
(Yoshikane et al., 2007)
Progenitor genotype
P{GT1}NAT1BG02338
(Yoshikane et al., 2007)
Cytology
Description

Excision of the progenitor insertion resulting in a 1.7kb genomic deletion that removes part of the first intron and 123bp at the 5' end of the second exon of NAT1 transcript 'a', and part of the first intron, all of the second exon and second intron, and 123bp at the 5' end of the third exon of NAT1 transcript 'b'.

(Yoshikane et al., 2007)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Lethal from embryonic to pupal stages, with 16% of homozygotes dying at the embryonic stage and 60% at the pupal stage. Most pupae stopped development in the early pupal period, displaying a misshapen puparium. The majority of mutants fail to shorten their body to form the characteristic shape of a prepupa and form long prepupae instead, also failing to evert anterior spiracles. Very rare mutant animals reach pharate adult stage - these show abnormal body proportions, and some are headless. Larval wing, haltere and eye-antennal imaginal discs are significantly smaller than wild type.

      NAT1ex1 mutants frequently have extra scutellar bristles on the scutellum.

      In contrast to wild type where the larval salivary gland degenerates early in the pupal stage, the gross structure of the salivary gland is still intact 24h after puparium formation.

      (Yoshikane et al., 2007)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      NAT1ex1 is rescued by NAT1+t12.6

      (Yoshikane et al., 2007)
      Comments

      NAT1+t12.6 completely rescues the lethality associated with NAT1ex1.

      (Yoshikane et al., 2007)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Df(dNAT1ex1)
      (Yoshikane et al., 2007)
      NAT1ex1
      dNATex1
      (Yoshikane et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)