FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\fweRNAi.UASp.Shp
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General Information
Symbol
Dmel\fweRNAi.UASp.Shp
Species
D. melanogaster
Name
FlyBase ID
FBal0302484
Feature type
allele
Associated gene
Dmel\fwe
Associated Insertion(s)
Carried in Construct
P{UASp-fwe.RNAi.Shp}
Key Links
Transgenic product class
RNAi_reagent
(Merino et al., 2013)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Merino et al., 2013)
Mutagen
in vitro construct
(Merino et al., 2013)
Progenitor genotype
Carried in construct
P{UASp-fwe.RNAi.Shp}
Cytology
Description

UASp regulatory sequences drive expression of a short inverted repeat targeting the fwe Lose-B isoform C-terminal domain, a sequence that is also contained in the 5' UTR of the Lose-A isoform.

(Merino et al., 2013)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
fwe
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Knocking down the fwe lose-A and lose-B isoforms through expression of fwedsRNA.Scer\UAS.Shp under the control of Scer\GAL4GMR.PF results in an almost complete reduction in the physiological peripheral photoreceptor cell death seen in control pupae.

      (Merino et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of fwedsRNA.P\T.Scer\UAS.Shp in the loser cells under the control of Scer\GAL4αTub84B.PBb does not suppress the increase in wild type 'loser' clone splitting seen when cell competition is induced in the wing disc through generation of wild type clones in super-competitive MycαTub84B.PBb-expressing tissue.

      (Levayer et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      fweRNAi.UASp.Shp
      fwedsRNA.P\T.Scer\UAS.Shp
      fwedsRNA.Scer\UAS.Shp
      fwedsRNA.UASp.Shp
      Name Synonyms
      Secondary FlyBase IDs
        References (3)