FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\upd1os-s
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General Information
Symbol
Dmel\upd1os-s
Species
D. melanogaster
Name
FlyBase ID
FBal0302830
Feature type
allele
Associated gene
Dmel\upd1
Associated Insertion(s)
Carried in Construct
Also Known As
oss
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
spontaneous
Progenitor genotype
Caused by aberration
Ab(1)oss
Cytology
Description

The exact aberration could not be identified but complementation and expression data show that Ab(1)oss disrupts the function of upd1 and upd3, represented by the alleles upd1os-s and upd3os-s.

(Wang et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
       

      In a tuberculosis model by abdominal injection with Mycobacterium marinum, Ab(1)oss (affecting both upd1, upd3) homozygous mutant adult flies present a significant decrease in the bacterial burden, and significant increases in the survival and hemocyte numbers upon infection, as compared to wild-type control flies.

      (Péan et al., 2017)
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Other
      Statement
      Reference

      upd1os-s, upd3os-s has hemocyte | increased number | adult stage | conditional phenotype

      (Péan et al., 2017)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Ab(1)oss (affecting both upd1, upd3) homozygous mutant adults present a significant decrease in the bacterial burden, and significant increases in the survival and hemocyte numbers upon infection with Mycobacterium marinum, as compared to wild-type controls; non-infected individuals present similar survival and hemocyte numbers as compared to wild-type controls.

      (Péan et al., 2017)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (12)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      oss
      (Péan et al., 2017, Wang et al., 2014)
      upd1os-s
      Name Synonyms
      Secondary FlyBase IDs
        References (3)