FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\AdipoR27
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General Information
Symbol
Dmel\AdipoR27
Species
D. melanogaster
Name
FlyBase ID
FBal0302952
Feature type
allele
Associated gene
Dmel\AdipoR
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Laws et al., 2015)
Mutagen
FLPase
(Laws et al., 2015)
Progenitor genotype
PBac{PB}AdipoRc02150
(Laws et al., 2015)
PBac{WH}AdipoRf05395
(Laws et al., 2015)
Cytology
Description

FLP-mediated recombination between PBac{WH}AdipoRf05395 and PBac{PB}AdipoRc02150 has resulted in deletion of AdipoR.

(Laws et al., 2015)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:22,543,854..22,547,787 [-]
Comment:

Scer\FRT-mediated recombination between the two progenitor insertions has resulted in the deletion of the genomic sequence between them.

(Laws et al., 2015)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Comparable frequencies of female S-phase germline stem cells (GSCs) are seen in AdipoR27 mutant clones and wild type controls raised on either a rich or poor diet. The number of progeny are also equivalent, and an equal number of two, four, eight and 16 cell cysts are seen. Vitellogenesis is unaffected. AdipoR27 mutant GSCs are lost at a higher rate than controls on both rich and poor diets, although the increase is greater on rich diets than on poor diets. There is no evidence of increased GSC apoptosis compared to controls. The number of cap cells in the stem cell niche is similar to controls.

      (Laws et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      AdipoR27 is rescued by AdipoRCH322-136M08

      (Laws et al., 2015)
      Partially rescued by

      AdipoR27 is partially rescued by AdipoRUASp.ACDE

      (Laws et al., 2015)

      AdipoR27 is partially rescued by AdipoRUASp.B

      (Laws et al., 2015)
      Comments

      Expression of AdipoRCH322-136M08 rescues the germline stem cell loss seen in AdipoR27 mutant clones.

      Expression of AdipoRScer\UAS.P\T.ACDE under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 partially rescues the female germline stem cell loss seen in AdipoR27 mutant clones.

      Expression of AdipoRScer\UAS.P\T.B under the control of Scer\GAL4nos.UTR.T:Hsim\VP16 partially rescues the female germline stem cell loss seen in AdipoR27 mutant clones.

      (Laws et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      AdipoR27
      (Laws et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)