FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Mmus\PrnpUAS.cMa
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General Information
Symbol
Mmus\PrnpUAS.cMa
Species
M. musculus
Name
Saccharomyces cerevisiae UAS construct a of Murali
FlyBase ID
FBal0303919
Feature type
allele
Associated gene
Mmus\Prnp
Associated Insertion(s)
Carried in Construct
P{UAS-Prnp.M}
Transgenic product class
cDNA
(Murali et al., 2014)
wild_type
(Murali et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Murali et al., 2014)
wild_type
(Murali et al., 2014)
Mutagen
in vitro construct
(Murali et al., 2014)
Progenitor genotype
Carried in construct
P{UAS-Prnp.M}
Cytology
Description

UASt regulatory sequences drive expression of a Mmus\Prnp cDNA.

(Murali et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Mmus\Prnp
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Mmus\PrnpScer\UAS.cMa under the control of Scer\GAL4ChAT.7.4 (limited to the adult stages using Scer\GAL80) display climbing defects. Climbing behavior is restored when the flies are returned to the permissive temperature following a two-, three- or four-day pulse of expression. An increased proportion of flies show climbing ability following 10 days of recovery compared with those that only received the pulse.

      Cholinergic neurons from adult brains expressing Mmus\PrnpScer\UAS.cMa under the control of Scer\GAL4ChAT.7.4 exhibit reduced spontaneous activity compared with controls. Activity is restored when the flies are returned to the permissive temperature for 10 days following a two-, three- or four-day pulse of expression.

      (Murali et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Mmus\PrnpScer\UAS.cMa
      Mmus\PrnpUAS.cMa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Murali
      Secondary FlyBase IDs
        References (2)