FB2026_03 , released September 17, 2026
Allele: Dmel\Lst1
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General Information
Symbol
Dmel\Lst1
Species
D. melanogaster
Name
FlyBase ID
FBal0305235
Feature type
allele
Associated gene
Dmel\Lst
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Alfa et al., 2015)
Mutagen
P-element activity
(Alfa et al., 2015)
Progenitor genotype
P{EP}G2424
(Alfa et al., 2015)
Cytology
Description

Imprecise excision of the progenitor insertion resulting in a 1,946 bp deletion (2R: 12462183.12464128 in the genome assembly release r5.52), only removing the Lst gene including the entire coding region.

(Alfa et al., 2015)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:16,574,678..16,576,623 [-]
Comment:

A 1,946 bp deletion resulting from the imprecise excision of P{EP}G2424 was mapped to 2R: 12462183.12464128 in Release 5 coordinates.

(Alfa et al., 2015)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  obesity
      CEA
      (Alfa et al., 2015)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Lst1 mutants are hypoglycemic and short-lived compared to controls. They are also obese: triglyceride content is elevated to 150% of control values. The Insulin Producing Cells are necessary for this obesity as this phenotype is not observed if these cells are electrically silenced (using Scer\GAL4Ilp2.215-1 and Hsap\KCNJ2Scer\UAS.T:Avic\GFP-EGFP).

      Starvation-induced lipid depletion remains fully intact in Lst1 mutants and is even slightly elevated. Mutants then rapidly accumulate triglycerides upon re-feeding and display significant obesity after only 24 hr.

      (Alfa et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Lst1 is rescued by LstRA.UAS/Scer\GAL4Akh.PG

      (Alfa et al., 2015)
      Comments

      Scer\GAL4Akh.PG-mediated expression of LstRA.Scer\UAS in the corpora cardiaca cells rescues the obesity of Lst1 animals.

      (Alfa et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Lst1
      lst1
      (Alfa et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)