FB2026_02 , released June 18, 2026
Allele: Dmel\pasi1Δ
Open Close
General Information
Symbol
Dmel\pasi1Δ
Species
D. melanogaster
Name
FlyBase ID
FBal0316520
Feature type
allele
Associated gene
Dmel\pasi1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Deligiannaki et al., 2015)
Progenitor genotype
P{EP}G4182
(Deligiannaki et al., 2015)
Caused by aberration
Df(3R)pasi1Δ
Cytology
Description

Imprecise excision of the progenitor, resulting in deletion of the entire pasi1 locus (and 59bp of the 3' UTR of CG7379).

(Deligiannaki et al., 2015)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:17,794,826..17,796,435 [+]
Comment:

1.6 kb deletion resulting from the imprecise excision of P{EP}G4182 removes sequences spanning 3R:17794826..17796435 .

(Deligiannaki et al., 2015)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      pasi1Δ or pasi1Δ/Df(3R)ED5785 or pasi1Δ/Df(3R)BSC566 embryos have a leaky blood-brain barrier. The number and positions of subperineurial glia are normal. Tracheal tubes of these mutants do not fill with air - the tracheal barrier is also compromised - and dorsal trunks are excessively elongated and convoluted. Septate junctions appear discontinuous and severely disorganized at the blood-brain barrier of pasi1Δ embryos. At embryonic stage 15, septate junction markers are also mislocalized in the hindgut and trachea.

      (Deligiannaki et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The leaky blood-brain barrier phenotype of pasi1Δ embryos is not rescued by Scer\GAL4repo-mediated expression of pasi2Scer\UAS.cDa.

      (Deligiannaki et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      pasi1Δ is rescued by pasi1UAS.cDa/Scer\GAL4repo

      (Deligiannaki et al., 2015)

      pasi1Δ is rescued by Scer\GAL4repo/pasi1UAS.GFP

      (Deligiannaki et al., 2015)
      Not rescued by

      pasi1Δ is not rescued by pasi1UAS.cDa/Scer\GAL4repo

      (Deligiannaki et al., 2015)
      Comments

      Scer\GAL4repo-mediated expression of pasi1Scer\UAS.cDa restores blood-brain barrier function, but not the tracheal defects, in pasi1Δ embryos.

      Scer\GAL4repo-mediated expression of pasi1Scer\UAS.T:Avic\GFP restores blood-brain barrier function to pasi1Δ embryos.

      (Deligiannaki et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      pasi1Δ
      (Deligiannaki et al., 2015)
      pasiflora1Δ
      (Deligiannaki et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)