FB2026_02 , released June 18, 2026
Allele: Dmel\Spt-IUAS.cOa
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General Information
Symbol
Dmel\Spt-IUAS.cOa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Oswald
FlyBase ID
FBal0317110
Feature type
allele
Associated gene
Dmel\Spt-I
Associated Insertion(s)
Carried in Construct
P{UAS-Spt-I.O}
Key Links
Transgenic product class
wild_type
(Oswald et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Oswald et al., 2015)
Mutagen
in vitro construct
(Oswald et al., 2015)
Progenitor genotype
Carried in construct
P{UAS-Spt-I.O}
Cytology
Description

UASt regulatory sequences drive expression of Spt-I.

(Oswald et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Spt-I
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Spt-IScer\UAS.cOa using Scer\GAL4ppk.PG produces subtle, yet statistically significant reduction in dendrite arborization compared with wild-type.

      (Oswald et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments

      Global expression of Spt-IScer\UAS.cOa under the control of Scer\GAL4αTub84B.PL is sufficient to rescue trans-heterozygous Spt-I mutant combinations, allowing survival to adulthood. Expression of Spt-IScer\UAS.cOa in neurons (Scer\GAL4elav.PU) or muscle (Scer\GAL4Mhc.PW) fails to rescue Spt-I mutants to adulthood.

      (Oswald et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Spt-IScer\UAS.cOa
      Spt-IUAS.cOa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Oswald
      Secondary FlyBase IDs
        References (1)