FB2026_02 , released June 18, 2026
Allele: Dmel\St(SD)1
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General Information
Symbol
Dmel\St(SD)1
Species
D. melanogaster
Name
FlyBase ID
FBal0318084
Feature type
allele
Associated gene
St(SD)
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
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    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
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        Expression Data
        Reporter Expression
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        Marker for
        Reflects expression of
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        Disease-implicated variant(s)
         
        Phenotypic Data
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        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        RanGAPβTub85D.PK causes very strong segregation distortion in the presence of the "SD-5[R7]" chromosome (E(SD)1, Rspi, M(SD)1, St(SD)1) over a target homolog chromosome carrying Rspss. Segregation distortion does not occur if the target homolog chromosome carries Rspi in place of Rspss. Overexpression of RanGAPβTub85D.PK does not cause segregation distortion in the presence of the "SD-5[R16]" chromosome (which carries a strong suppressor of SD in addition to RanGAPSd, E(SD)1, Rspi, M(SD)1, St(SD)1) over a target homolog chromosome carrying Rspss. Segregation distortion can occur in the absence of RanGAPSd if flies are homozygous for E(SD)1 : Flies carrying chromosome SD-5[R7] (E(SD)1, Rspi M(SD)1 St(SD)1) / chromosome ReR-5 (E(SD)1 Rsps) exhibit moderate segregation distortion (k=0.74 +/-0.014) against ReR-5. This can be suppressed by the presence of RanβTub85D.PK or Rcc1βTub85D.PK. RanβTub85D.PK and Rcc1βTub85D.PK can both suppress the segregation distortion phenotype caused by RanGAPβTub85D.PK in the presence of the "SD-5[R7]" chromosome (E(SD)1, Rspi, M(SD)1, St(SD)1) over a target homolog chromosome carrying Rspss.

        (Kusano et al., 2002)

        Segregation distortion is not seen RanGAPSd.tPa.1 flies in the presence of E(SD)1 or of the SD-5[R7] chromosome (E(SD)1, Rspi, M(SD)1, St(SD)1). RanGAPSd.tPa induces high levels of segregation distortion in the presence of the SD-5[R7] chromosome (E(SD)1, Rspi, M(SD)1, St(SD)1) over a target homolog chromosome carrying Rspss or Rsps.

        (McLean et al., 1994)
        Xenogenetic Interactions
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        Complementation and Rescue Data
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        Mutant
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        Stocks (4)
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        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        St(SD)1
        Name Synonyms
        Secondary FlyBase IDs
          References (2)