FB2026_03 , released September 17, 2026
Allele: Dmel\WRNexoD229V
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General Information
Symbol
Dmel\WRNexoD229V
Species
D. melanogaster
Name
FlyBase ID
FBal0318456
Feature type
allele
Associated gene
Dmel\WRNexo
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Bolterstein et al., 2014)
Progenitor genotype
Cytology
Description

Amino acid replacement: D229V.

(Boubriak et al., 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:18,365,042..18,365,042 [-]
Nucleotide change:

A18365042T

Amino acid change:

D229V | WRNexo-PA; D230V | WRNexo-PB; D229V | WRNexo-PC

Reported amino acid change:

D229V

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Boubriak et al., 2009)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      WRNexoD229V/WRNexoD229V flies have normal survival rates in response to camptothecin or topotecan treatment and are not sensitive to bleomycin.

      WRNexoΔ/WRNexoD229V mutants do not have reduced hatching frequency or hydroxyurea sensitivity (except hatching frequency is significantly reduced when embryos are laid by WRNexoΔ females mated with WRNexoD229V/WRNexoΔ males).

      (Bolterstein et al., 2014)

      Mitotic recombination rates are approximately doubled in WRNexoe04496/Df(3R)Exel6178 flies, compared to WRNexoe04496/WRNexoe04496; rates of recombination in WRNexoe04496/WRNexoD229V are much lower (though still higher than WRNexoe04496/+).

      (Boubriak et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      WRNexoD229V/WRNexoD229V mus81Nhe/mus81Nhe double mutants survive to adulthood and are healthy.

      (Bolterstein et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      CG7670D229V
      (Boubriak et al., 2009)
      WRNexoD229V
      (Bolterstein et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)