FB2026_02 , released June 18, 2026
Allele: Dmel\Nopp140Δ
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General Information
Symbol
Dmel\Nopp140Δ
Species
D. melanogaster
Name
FlyBase ID
FBal0319762
Feature type
allele
Associated gene
Dmel\Nopp140
Associated Insertion(s)
PBac{RB5.WH5}Nopp140Δ
Carried in Construct
Also Known As
KO121
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(He et al., 2015)
Mutagen
FLPase
(He et al., 2015)
Progenitor genotype
PBac{WH}P5CDh1f04633
(He et al., 2015)
PBac{RB}e01407b
(He et al., 2015)
Associated Insertion(s)
PBac{RB5.WH5}Nopp140Δ
Caused by aberration
Df(3L)Nopp140Δ
Cytology
Description

Recombination between the progenitor insertions results in complete deletion of Nopp140 (Nopp140Δ) and removal of the 3' coding region of P5CDh1) (P5CDh1f04633.Δ).

(He et al., 2015)
Allele components
Component
Use(s)
Inserted element
PBac{RB5.WH5}
Regulatory region(s)
UAS
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous Nopp140Δ mutants show significantly reduced hatching rate compared to wild-type and do not survive beyond the second larval instar.

      Polyploid midgut cells of Nopp140Δ/Nopp140Δ second instar larvae are devoid of free cytoplasmic ribosomes and instead display what appear to be ribosomal aggregates not normally seen in the cytoplasm of wild-type cells, they also contain unusually high numbers of dispersed or clustered virus-like particles in the nuclei.

      (He et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      The presence of PBac{RB5.WH5}Nopp140Δ was verified by PCR.

      (He et al., 2015)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      KO121
      (DeLeo et al., 2021, Baral and DiMario, 2019)
      Nopp140KO121
      (Baral et al., 2020)
      Nopp140Δ
      Name Synonyms
      Secondary FlyBase IDs
        References (4)