FB2026_03 , released September 17, 2026
Allele: Dmel\Sdc::HsapPDGFRBTM-Swap.UAS.Tag:MYC
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General Information
Symbol
Dmel\Sdc::Hsap\PDGFRBTM-Swap.UAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0319784
Feature type
allele
Associated gene
Sdc::Hsap\PDGFRB
Associated Insertion(s)
Carried in Construct
P{UAS-Sdc.TM-Swap}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Nguyen et al., 2016)
Progenitor genotype
Carried in construct
P{UAS-Sdc.TM-Swap}
Cytology
Description

UAS regulatory sequences drive expression of a fusion protein consisting of Sdc in which the transmembrane domain has been replaced by the transmembrane domain of Hsap\PDGFRB (which lacks dimerisation ability, in contrast to that of Sdc). The protein is tagged in the extracellular domain with a 5x Tag:MYC tag.

(Nguyen et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Sdc::Hsap\PDGFRB
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Sdc::Hsap\PDGFRBTM-Swap.Scer\UAS.T:Hsap\MYC driven post-synaptically by Scer\GAL4how-24B leads to a significant increase in the number of boutons per neuromuscular junction, compared to controls.

      (Nguyen et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Sdc10608/Df(2R)48 third instar larvae (in which Sara function has been rescued by SaraUbi.PJ) have a decrease in the number of boutons per neuromuscular junction, compared to controls; this phenotype is rescued by expression of Sdc::Hsap\PDGFRBTM-Swap.Scer\UAS.T:Hsap\MYC driven by Scer\GAL4how-24B.

      (Nguyen et al., 2016)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Sdc::Hsap\PDGFRBTM-Swap.Scer\UAS.T:Hsap\MYC
      Sdc::Hsap\PDGFRBTM-Swap.UAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (1)