FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\SOD1G93A.UAS.Tag:FLAG
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General Information
Symbol
Hsap\SOD1G93A.UAS.Tag:FLAG
Species
H. sapiens
Name
FlyBase ID
FBal0319857
Feature type
allele
Associated gene
Hsap\SOD1
Associated Insertion(s)
Carried in Construct
P{UAS-hSOD1.G93A}
Key Links
Transgenic product class
missense_variant
(Gallart-Palau et al., 2016)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Gallart-Palau et al., 2016)
Mutagen
in vitro construct
(Gallart-Palau et al., 2016)
Progenitor genotype
Carried in construct
P{UAS-hSOD1.G93A}
Cytology
Description

UASt regulatory sequences drive expression of Hsap\SOD1 carrying the familial amyotrophic lateral sclerosis (FALS)-associated G93A amino acid replacement. The protein tagged with Tag:FLAG.

(Gallart-Palau et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\SOD1
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  amyotrophic lateral sclerosis type 1
      CEA
      (Gallart-Palau et al., 2016)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (Gallart-Palau et al., 2016)
      SOD1:p.Gly94Ala
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      SOD1:p.Gly93Ala
      Associated human disease model(s)
      External database links
      ClinVar: SOD1_14760
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Around 30-40% of flies with expression of Hsap\SOD1G93A.Scer\UAS.T:Zzzz\FLAG driven by Scer\GAL4how-24B have a held up (vertically) wing phenotype and are flightless. Muscle fibers in Scer\GAL4how-24B>Hsap\SOD1G93A.Scer\UAS.T:Zzzz\FLAG flies show similar organization to controls (Scer\GAL4how-24B>Hsap\SOD1Scer\UAS.T:Zzzz\FLAG), but mitochondria are impaired, and often mitochondria are elongated or swollen, with autophagosome-like features. Scer\GAL4how-24B>Hsap\SOD1G93A.Scer\UAS.T:Zzzz\FLAG flies (with or without upheld wings) show progressive deficits in climbing ability compared to controls; mutant flies (even more so those with upheld wings) have a shorter lifespan compared to controls.

      (Gallart-Palau et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\SOD1G93A.Scer\UAS.T:Zzzz\FLAG
      Hsap\SOD1G93A.UAS.Tag:FLAG
      hSOD1G93A
      (Gallart-Palau et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)