FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\kelQSTN.UASp
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General Information
Symbol
Dmel\kelQSTN.UASp
Species
D. melanogaster
Name
FlyBase ID
FBal0319940
Feature type
allele
Associated gene
Dmel\kel
Associated Insertion(s)
Carried in Construct
P{UASp-kel.QSTN}
Key Links
Transgenic product class
missense_variant
(Hudson et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Hudson et al., 2015)
Mutagen
in vitro construct
(Hudson et al., 2015)
Progenitor genotype
Carried in construct
P{UASp-kel.QSTN}
Cytology
Description

UASp regulatory sequences drive expression of kel that contains the amino acid replacements Q200A, S201A, T232A and N234A.

(Hudson et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
kel
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      kelQSTN.UASp/Scer\GAL4VP16.mat.αTub67C rescues kelDE1

      (Hudson et al., 2015)
      Partially rescues

      Scer\GAL4VP16.otu/kelQSTN.UASp partially rescues kelDE1

      (Hudson et al., 2015)
      Comments

      Expression of kelQSTN.Scer\UAS.P\T under the control of Scer\GAL4otu.T:Hsim\VP16 (resulting in a low-level expressing) fully restores the small oocyte phenotype but only partially rescues the nurse cell ring canal phenotype (thickening of the F-actin cytoskeleton) characteristic for kelDE1 homozygote mutant females, while expression under the Scer\GAL4mat.αTub67C.T:Hsim\VP16 driver (resulting in a high-level expression) fully rescues both the ring canal and small oocyte phenotypes. Expression using either of the two drivers restores the kelDE1 flies to fertility.

      (Hudson et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      KelchQSTN
      (Hudson et al., 2015)
      kelQSTN.Scer\UAS.P\T
      kelQSTN.UASp
      Name Synonyms
      Secondary FlyBase IDs
        References (1)