FB2026_02 , released June 18, 2026
Allele: Dmel\E(spl)m5-HLHC37S
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General Information
Symbol
Dmel\E(spl)m5-HLHC37S
Species
D. melanogaster
Name
FlyBase ID
FBal0319998
Feature type
allele
Associated gene
Dmel\E(spl)m5-HLH
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Bivik et al., 2016)
Progenitor genotype
Cytology
Description

Amino acid replacement: C37S.

(Bivik et al., 2016)

Nucleotide substitution: T173A.

(Bivik et al., 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:26,029,544..26,029,544 [-]
Nucleotide change:

T26029544A

Reported nucleotide change:

T173A

Amino acid change:

C37S | E(spl)m5-HLH-PA

Reported amino acid change:

C37S

(Bivik et al., 2016)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      E(spl)m5-HLHC37S/Df(3R)BSC751 (but not E(spl)m5-HLHC37S/E(spl)m5-HLHK72stop or E(spl)m5-HLHC37S/E(spl)m5-HLHQ127stop) mutant embryos display a significant increase in the number of Ap neurons, and E(spl)m5-HLHC37S/Df(3R)BSC751 mutants display a significant increase in the number of EL neurons, as compared with controls.

      (Bivik et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      E(spl)m5-HLHC37S
      m5C37S
      (Bivik et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)