FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\GBA1WT.UAS
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General Information
Symbol
Hsap\GBA1WT.UAS
Species
H. sapiens
Name
FlyBase ID
FBal0320435
Feature type
allele
Associated gene
Hsap\GBA1
Associated Insertion(s)
Carried in Construct
M{UAS-hGBA.WT}
Key Links
Transgenic product class
wild_type
(Sanchez-Martinez et al., 2016)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Sanchez-Martinez et al., 2016)
Mutagen
in vitro construct
(Davis et al., 2016, Sanchez-Martinez et al., 2016)
Progenitor genotype
Carried in construct
M{UAS-hGBA.WT}
Cytology
Description

UASt regulatory sequences drive expression of the wild-type Hsap\GBA open reading frame.

(Sanchez-Martinez et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\GBA1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Lewy body dementia
      modeled by Gba1bMB03039
      (Jewett et al., 2021)
      ameliorates  Parkinson's disease
      modeled by Gba1bMB03039
      (Jewett et al., 2021)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\GBAWT.Scer\UAS under the control of Scer\GAL4elav.PU does not lead to climbing defects, dopaminergic neuron loss in adult brains, abnormal endoplasmic reticulum morphology in the larval salivary gland, nor any significant difference in lifespan, and does not result in any overt degeneration of the eye, even after extensive aging, as compared to controls.

      (Sanchez-Martinez et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Created by Alex Whitworth (MRC Mitochondrial Biology Unit).

      (Davis et al., 2016)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\GBA1WT.UAS
      Hsap\GBAWT.Scer\UAS
      Hsap\GBAWT.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (3)