FlyBase Allele Report: Dmel\OSCP1[UAS.cHa]

General Information

Symbol

Dmel\OSCP1^UAS.cHa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Huu

FlyBase ID

FBal0320769

Feature type

allele

Associated gene

Dmel\OSCP1

Associated Insertion(s)

Carried in Construct

P{UAS-OSCP1.H}

Key Links

Transgenic product class

wild_type

(Huu et al., 2015)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Huu et al., 2015)

Mutagen

in vitro construct

(Huu et al., 2015)

Progenitor genotype

Carried in construct

P{UAS-OSCP1.H}

Cytology

Description

UASt regulatory sequences drive expression of the full coding sequence of OSCP1.

(Huu et al., 2015)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

OSCP1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death | third instar larval stage, with Scer\GAL4^GMR.PS

(Huu et al., 2015)

increased occurrence of cell division | third instar larval stage, with Scer\GAL4^GMR.PS

(Huu et al., 2015)

visible, with Scer\GAL4^91Y

(Huu et al., 2015)

visible, with Scer\GAL4^ey.PU

(Huu et al., 2015)

visible, with Scer\GAL4^GMR.PS

(Huu et al., 2015)

Phenotype Manifest In

eye, with Scer\GAL4^91Y

(Huu et al., 2015)

eye, with Scer\GAL4^ey.PU

(Huu et al., 2015)

eye, with Scer\GAL4^GMR.PS

(Huu et al., 2015)

eye disc posterior compartment | third instar larval stage, with Scer\GAL4^GMR.PS

(Huu et al., 2015)

ommatidium, with Scer\GAL4^GMR.PS

(Huu et al., 2015)

Detailed Description

Statement

Reference

Expression of OSCP1^Scer\UAS.cHa under the control of Scer\GAL4^GMR.PS results in a rough eye phenotype in adults, with fusion of ommatidia, but no significant difference in eye size; and the eye discs of third instar larvae show significantly increased levels of both apoptosis and cell proliferation, and increased numbers of cells in S-phase, in the region posterior to the morphogenetic furrow, as compared to controls.

Expression of OSCP1^Scer\UAS.cHa under the control of Scer\GAL4^ey.PU or Scer\GAL4^91Y results in a weak rough eye phenotype.

Expression of OSCP1^Scer\UAS.cHa under the control of Scer\GAL4^arm.PU, Scer\GAL4^c179, Scer\GAL4^dpp.PU, Scer\GAL4^Act5C.PU, Scer\GAL4^Dll.PU, Scer\GAL4^48Y, Scer\GAL4^pnr.PU, or Scer\GAL4^en.PU, does not result in a detectable phenotype.

(Huu et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Diap1^Scer\UAS.cUa rescues the rough eye phenotype of adults, and the eye disc apoptosis and proliferation phenotype of larvae expressing OSCP1^Scer\UAS.cHa under the control of Scer\GAL4^GMR.PS.

(Huu et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

OSCP1^Scer\UAS.cHa

OSCP1^UAS.cHa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Huu

Secondary FlyBase IDs

References (1)

Report Sections

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