FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\SypFlyFos-024580
Open Close
General Information
Symbol
Dmel\SypFlyFos-024580
Species
D. melanogaster
Name
FlyBase ID
FBal0320790
Feature type
allele
Associated gene
Dmel\Syp
Associated Insertion(s)
Carried in Construct
P{Syp.FlyFos-024580}
Also Known As
sypRescue
Key Links
Transgenic product class
wild_type
(McDermott et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(McDermott et al., 2014)
Mutagen
in vitro construct
(McDermott et al., 2014)
Progenitor genotype
Carried in construct
P{Syp.FlyFos-024580}
Cytology
Description

Genomic fragment (derived from the FlyFos024580 fosmid) which covers all Syp isoforms except A and H.

(McDermott et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
Syp
Encoded product / tool
Syp
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      SypFlyFos-024580 partially rescues Df(3R)BSC124/Sype00286

      (Halstead et al., 2014)

      SypFlyFos-024580 partially rescues Df(3R)BSC124/Sype00286

      (McDermott et al., 2014)

      SypFlyFos-024580 partially rescues Sype00286

      (McDermott et al., 2014)
      Comments

      Expression of SypFlyFos-024580 rescues the excitatory junction potential, paired pulse ratio, synaptic vesicle phenotypes, and partially rescues the defective endocytosis of Sype00286/Df(3R)BSC124 mutants.

      (Halstead et al., 2014)

      SypFlyFos-024580 rescues synaptic overgrowth (increases in branch and bouton number) phenotypes at the NMJ, but not myonuclear distribution defects, of Sype00286/Sype00286 or Sype00286/Df(3R)BSC124 third instar larvae.

      (McDermott et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      SypFlyFos-024580
      sypRescue
      (Halstead et al., 2014, McDermott et al., 2014)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)