FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: HHV-5\UL122hsp70.cSa
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General Information
Symbol
HHV-5\UL122hsp70.cSa
Species
C. Human herpesvirus 5
Name
FlyBase ID
FBal0321252
Feature type
allele
Associated gene
HHV-5\UL122
Associated Insertion(s)
Carried in Construct
P{hsp70-IE.S}
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Steinberg et al., 2008)
Progenitor genotype
Carried in construct
P{hsp70-IE.S}
Cytology
Description

A 4.5kb genomic region containing the coding regions of Zzzz\UL123 and Zzzz\UL122 (without the Major Immediate Early promoter).

(Steinberg et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
Hsp70
Encoded product / tool
HHV-5\UL122
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Following heat shock for 8 minutes at 120-190 minutes old (stages 5-7), between 34% and 43% of embryos expressing Zzzz\UL123hsp70.cSa fail to hatch, compared to 18% in wild type. Unhatched wild type embryos do not show any obvious abnormalities, whereas embryos expressing Zzzz\UL123hsp70.cSa display extremely abnormal embryonic morphology and appear disorganised and fragmented. In some embryos delaminated cells appear to be floating within the vitelline envelope. The adherens junctions (AJs) appear irregularly spaced and disorganised and are sometimes detected at more basal domains than in wild type.

      (Steinberg et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      HHV-5\UL122hsp70.cSa
      Zzzz\UL122hsp70.cSa
      Name Synonyms
      heat shock construct of Steinberg
      Secondary FlyBase IDs
      • FBal0320638
      • FBal0280520
      References (2)