FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Oari\PrPAHQ.UAS
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General Information
Symbol
Oari\PrPAHQ.UAS
Species
O. aries
Name
FlyBase ID
FBal0321254
Feature type
allele
Associated gene
Oari\PrP
Associated Insertion(s)
Carried in Construct
M{UAS-ovPrP.AHQ}
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Thackray et al., 2012)
Progenitor genotype
Carried in construct
M{UAS-ovPrP.AHQ}
Cytology
Description

UASt regulatory sequences drive expression of mature length Oari\PrP (amino acid residues 25-231) encoding the naturally occurring "AHQ" polymorphic variant (Ala[136] Leu[141] His[154] Gln[171]). The protein is flanked at the N-terminal end by an insect secretion signal peptide and at the C-terminal end by the Oari\PrP glycosylphosphatidylinositol anchor signal sequence.

(Thackray et al., 2012)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Oari\PrP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  scrapie
      CEA
      (Thackray et al., 2014)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The expression of Oari\PrPAHQ.Scer\UAS under the control of Scer\GAL4elav-C155 results in a decrease in adult lifespan compared to controls.

      (Thackray et al., 2012)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Oari\PrPAHQ.Scer\UAS
      Oari\PrPAHQ.UAS
      Zzzz\PrPAHQ.Scer\UAS
      Name Synonyms
      Secondary FlyBase IDs
      • FBal0320640
      • FBal0282640
      References (3)