FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Cint\NDXUAS.cGa
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General Information
Symbol
Cint\NDXUAS.cGa
Species
C. intestinalis
Name
FlyBase ID
FBal0321421
Feature type
allele
Associated gene
Cint\NDX
Associated Insertion(s)
Carried in Construct
PBac{UAS-NDX.G}
Transgenic product class
wild_type
(Gospodaryov et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Gospodaryov et al., 2014)
Mutagen
in vitro construct
(Gospodaryov et al., 2014)
Progenitor genotype
Carried in construct
PBac{UAS-NDX.G}
Cytology
Description

UASt regulatory sequences drive expression of Cint\NDX.

(Gospodaryov et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Cint\NDX
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Flies (males and females that are 1, 2 or 3 weeks old) with expression of Cint\NDXScer\UAS.cGa driven by Scer\GAL4da.G32 survive significantly longer than controls after exposure to menadione (ROS generator). Scer\GAL4da.G32>Cint\NDXScer\UAS.cGa flies are also protected against thermal stresses, with significant decreases in recovery times (in both males and females, aged 1 or 3 weeks old) from cold- and heat-induced paralysis, as well as increased time of resistance to heat-shock before paralysis onset, compared to controls. Scer\GAL4da.G32>Cint\NDXScer\UAS.cGa flies also show modest resistance to starvation (increased survival time compared to controls), though this effect disappears when flies are cultured on a minimal agar-only diet. Flies (males and females) with expression of Cint\NDXScer\UAS.cGa driven by Scer\GAL4da.G32 have a significantly longer lifespan than controls on rich media, though this effect is mitigated by dietary restriction.

      (Gospodaryov et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of Cint\NDXScer\UAS.cGa and Cint\AOXScer\UAS.cFa driven by Scer\GAL4da.G32 results in partial lethality (significant decreases in the number of progeny) and significant delays in eclosion timing (slightly more than a day, and a further day with two copies of Cint\NDXScer\UAS.cGa) in male and female flies, compared to controls.

      Co-expression of Cint\AOXScer\UAS.cFa does not suppress lethality seen with expression of ND-39GD5150 or ND-19GD16787 driven by Scer\GAL4da.G32.

      (Gospodaryov et al., 2014)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Cint\NDXScer\UAS.cGa
      Cint\NDXUAS.cGa
      Name Synonyms
      Secondary FlyBase IDs
        References (3)