FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\BCL2L13ΔTM.UAS
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General Information
Symbol
Hsap\BCL2L13ΔTM.UAS
Species
H. sapiens
Name
FlyBase ID
FBal0321722
Feature type
allele
Associated gene
Hsap\BCL2L13
Associated Insertion(s)
Carried in Construct
P{UAS-hBCL2L13.ΔTM}
Key Links
Transgenic product class
inframe_deletion
(Nakazawa et al., 2016)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Nakazawa et al., 2016)
Mutagen
in vitro construct
(Nakazawa et al., 2016)
Progenitor genotype
Carried in construct
P{UAS-hBCL2L13.ΔTM}
Cytology
Description

UAS regulatory sequences drive expression of Hsap\BCL2L13 amino acid residues 1-435 and 454-459 (lacks the C-terminal transmembrane domain).

(Nakazawa et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\BCL2L13
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\BCL2L13ΔTM.Scer\UAS driven along the anterior-posterior compartment boundary by Scer\GAL4dpp.PU does not induce significant morphological changes in the wing vein compared to controls; expression driven in the dorsal mesothorax by Scer\GAL4pnr.PU does not result in significant morphological changes; expression driven in the posterior compartment of each segment of the embryo by Scer\GAL4en.PU does not induce lethality; expression driven in the eye by Scer\GAL4GMR.PS does not induce significant eye phenotypes in adults or caspase activation in the morphogenetic furrow of eye imaginal discs in third instar larvae (similar to controls). Though the shape of cone and pigment cells is similar to controls, Scer\GAL4GMR.PS>Hsap\BCL2L13ΔTM.Scer\UAS pupal retina 42hr after puparium formation show defects in ommatidia rotation; there are no significant signs of apoptosis being induced in the pupal retinae, similar to controls.

      (Nakazawa et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of BacA\p35Scer\UAS.cUa, Diap1Scer\UAS.cUa or Diap2GMR.PH or presence of DebclE26/+, DebclW105/+, DebclE26 BuffyH37/+, DebclW105 BuffyH37/+, BuffyH37/+, sesBorg/+, Ant2G0247 sesBG0247/+, Atg8aEP362 or schlankG0061 in Scer\GAL4GMR.PS>Hsap\BCL2L13ΔTM.Scer\UAS does not result in significant eye phenotypes.

      (Nakazawa et al., 2016)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\BCL2L13ΔTM.Scer\UAS
      Hsap\BCL2L13ΔTM.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (1)