FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\DISC1mtNLS1.UAS.Tag:HA
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General Information
Symbol
Hsap\DISC1mtNLS1.UAS.Tag:HA
Species
H. sapiens
Name
FlyBase ID
FBal0321729
Feature type
allele
Associated gene
Hsap\DISC1
Associated Insertion(s)
Carried in Construct
P{UAS-DISC1.mtNLS1.HA}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Furukubo-Tokunaga et al., 2016)
Progenitor genotype
Carried in construct
P{UAS-DISC1.mtNLS1.HA}
Cytology
Description

UAS regulatory sequences drive expression of Hsap\DISC1 carrying a mutation in the NLS1 nuclear localisation signal located near the N-terminus of the protein. The protein is tagged with Tag:HA.

(Furukubo-Tokunaga et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\DISC1
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The axonal branching of γ-neurons in MARCM somatic clones in the adult mushroom body expressing Hsap\DISC1mtNLS1.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4ey-OK107 is significantly reduced (both the number of branching points and the total branch length) compared to wild-type, dendritic branching however remains unaffected.

      Expression of Hsap\DISC1mtNLS1.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4tub.PU results in reduced total neuromuscular junction bouton area, although their number per junction is not decreased and neither is the number of axonal branching points.

      (Furukubo-Tokunaga et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\DISC1mtNLS1.Scer\UAS.T:Ivir\HA1
      Hsap\DISC1mtNLS1.UAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (2)