FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\wRNAi.GMR.cGa
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General Information
Symbol
Dmel\wRNAi.GMR.cGa
Species
D. melanogaster
Name
GMR construct of Gandhi
FlyBase ID
FBal0322778
Feature type
allele
Associated gene
Dmel\w
Associated Insertion(s)
Carried in Construct
P{GMR-w.RNAi.G}
Key Links
Transgenic product class
RNAi_reagent
(Gandhi et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Gandhi et al., 2015)
Mutagen
in vitro construct
(Gandhi et al., 2015)
Progenitor genotype
Carried in construct
P{GMR-w.RNAi.G}
Cytology
Description

The eye-specific GMR promoter drives expression of an inverted repeat of 629 bp from the third exon of the w gene, sandwiched between the second intron. This generates a hairpin dsRNA that targets the w gene for RNA--mediated knock-down.

(Gandhi et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
GMR
Encoded product / tool
w
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of wdsRNA.GMR.cGa results in loss of pigmentation in the adult eyes and white/very pale eye color.

      (Gandhi et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      wRNAi.GMR.cGa has abnormal eye color phenotype, suppressible | partially by Gas41[+]/Gas41f05565

      (Gandhi et al., 2015)

      wRNAi.GMR.cGa has visible | adult stage phenotype, suppressible | partially by Gas41[+]/Gas41f05565

      (Gandhi et al., 2015)

      wRNAi.GMR.cGa has abnormal eye color phenotype, suppressible | partially by Gas41[+]/Gas41NP2248

      (Gandhi et al., 2015)

      wRNAi.GMR.cGa has visible | adult stage phenotype, suppressible | partially by Gas41[+]/Gas41NP2248

      (Gandhi et al., 2015)

      wRNAi.GMR.cGa has abnormal eye color phenotype, suppressible | partially by Gas41f05565/Gas41NP2248

      (Gandhi et al., 2015)

      wRNAi.GMR.cGa has visible | adult stage phenotype, suppressible | partially by Gas41f05565/Gas41NP2248

      (Gandhi et al., 2015)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Combination of wdsRNA.GMR.cGa with Gas41f05565 or Gas41NP2248 individually in heterozygous or together in transheterozygous state, significantly ameliorates the loss of pigmentation in the adult eye induced by the wdsRNA.GMR.cGa RNAi.

      (Gandhi et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      wRNAi.GMR.cGa
      wdsRNA.GMR.cGa
      Name Synonyms
      GMR construct of Gandhi
      Secondary FlyBase IDs
        References (2)