FlyBase Allele Report: Dmel\Magi[ex214]

General Information

Symbol

Dmel\Magi^ex214

Species

D. melanogaster

Name

FlyBase ID

FBal0322787

Feature type

allele

Associated gene

Dmel\Magi

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - genetic evidence

amorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Zaessinger et al., 2015)

amorphic allele - molecular evidence

(Zaessinger et al., 2015)

Mutagen

P-element activity

(Zaessinger et al., 2015)

Progenitor genotype

P{GSV3}GS6093

(Zaessinger et al., 2015)

Cytology

Description

Deletion affecting the first three exons of Magi, removing the transcription start site, the translation start codon and the first half of the WW domain.

(Zaessinger et al., 2015)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | adult stage

(Zaessinger et al., 2015)

Phenotype Manifest In

Detailed Description

Statement

Reference

Magi^ex214 homozygote adults as well as Magi^ex214/Df(2R)Exel6072 transheterozygotes have slightly enlarged wings and frequently show a mild rough eye phenotype due to increased number of inter-ommatidial cells and bristles; numbers of photoreceptors, cone cells and primary pigment cells is normal.

Somatic clones of Magi^ex214 homozygous mutant cells in the pupal eye disc display defects in the morphology of adherens junction (AJ) with frequent gaps in the AJ structure (visualized by E-Cad staining), these defects appear only transiently during inter-ommatidial cell sorting and are not apparent at later stages.

(Zaessinger et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Enhanced by

Statement

Reference

Magi^ex214 has adherens junction | pupal stage | somatic clone phenotype, enhanceable by arm³/arm[+]

(Zaessinger et al., 2015)

Magi^ex214 has eye disc | pupal stage | somatic clone phenotype, enhanceable by arm³/arm[+]

(Zaessinger et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The high frequency of gaps in the structure of adherens junctions observed in somatic clones of Magi^ex214 homozygous cells in the pupal eye disc is strongly enhanced by combination with a single copy of the arm³ allele.

(Zaessinger et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Df(2R)Exel6072/Magi^ex214 is rescued by Magi^Ubi-p63E.PZ

(Zaessinger et al., 2015)

Partially rescued by

Df(2R)Exel6072/Magi^ex214 is partially rescued by Magi^{ΔWW.Ubi-p63E}

(Zaessinger et al., 2015)

Comments

The rough eye phenotype observed in Magi^ex214/Df(2R)Exel6072 adult transheterozygotes is fully or partially rescued by expression of Magi^Ubi-p63E.PZ or Magi^Ubi-p63E.PZ, respectively.

(Zaessinger et al., 2015)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Magi^ex214

(Zaessinger et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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