FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mei-W68Z4472
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General Information
Symbol
Dmel\mei-W68Z4472
Species
D. melanogaster
Name
FlyBase ID
FBal0322881
Feature type
allele
Associated gene
Dmel\mei-W68
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Bhagat et al., 2004)
Progenitor genotype
Cytology
Description

Amino acid replacement: I255N.

(Bhagat et al., 2004)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:19,458,873..19,458,873 [+]
Nucleotide change:

T19458873A

Amino acid change:

I255N | mei-W68-PA

Reported amino acid change:

I255N

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Bhagat et al., 2004)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      mei-W68Z4472/mei-W68Z4472 female meioses exhibit severe crossover frequency reduction along the X chromosome and chromosome 2, as compared to wild type. However, when mei-W68Z4472/mei-W68Z4472 females are irradiated to induce double stranded breaks, crossing over is efficiently induced.

      mei-W68L1/mei-W68Z4472 female meioses exhibit crossover frequency reduction in some, but not all, regions of chromosome 3, as compared to wild type.

      (Bhagat et al., 2004)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      mei-W68Z4472/mei-W68Z4472, mei-2181/mei-2181 double mutant females exhibit less crossing over following irradiation, as compared to mei-W68Z4472/mei-W68Z4472 single mutants.

      (Bhagat et al., 2004)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      mei-W68Z4472
      (Bhagat et al., 2004)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)