FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ncoa63PPXA.Tag:HA
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General Information
Symbol
Dmel\Ncoa63PPXA.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0323339
Feature type
allele
Associated gene
Dmel\Ncoa6
Associated Insertion(s)
Carried in Construct
P{3XHA-NcoA6.3PPXA}
Key Links
Transgenic product class
dominant_negative_variant
(Oh et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
dominant_negative_variant
(Oh et al., 2014)
Mutagen
in vitro construct
(Oh et al., 2014)
Progenitor genotype
Carried in construct
P{3XHA-NcoA6.3PPXA}
Cytology
Description

Genomic fragment encompassing Ncoa6 (BPRC clone CH322-05H20). Each of the 3 PPxY motifs in the Ncoa6 open reading frame has been mutated, resulting in a dominant-negative protein, and it is tagged with three tandem copies of Tag:HA.

(Oh et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
Ncoa6
Encoded product / tool
Ncoa6
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ncoa63PPXA.T:Ivir\HA1 homozygotes third instar larvae display increased levels of apoptotic marker (cleaved Casp3) in the wing discs.

      (Oh et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Ncoa63PPXA.T:Ivir\HA1
      Ncoa63PPXA.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (1)