Sce^I48A.gen mutant (both zygotically and maternally) embryos do not show any detectable homeotic transformations or cuticle defects but they arrest development at the end of embryogenesis. Development and patterning of peripheral nervous system and muscle tissues is also comparable to wild-type, but Sce^I48A.gen embryos occasionaly display aberrant neuronal or muscle fiber connections.

Embryos that are zygotically Sce^I48A.gen homozygous but had received maternal load of wild-type Sce complete all stages of larval development, pupate and a small fraction of them develop into pharate adults. These adults show a number of variable morphological defects (e.g. defective fusion of hemisegments in thoracic and abdominal segments and loss of macro- and microchaete in the area or leg morphology defects ranging from nearly normal to severely shortened and malformed) but no homeotic transformations.