FlyBase Allele Report: Dmel\mora[HMC06216]

General Information

Symbol

Dmel\mora^HMC06216

Species

D. melanogaster

Name

FlyBase ID

FBal0324101

Feature type

allele

Associated gene

Dmel\mora

Associated Insertion(s)

Carried in Construct

P{TRiP.HMC06216}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.HMC06216}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMC06216

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal mitotic cell cycle | embryonic stage | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

(Palumbo et al., 2020)

abnormal mitotic cell cycle | larval stage, with Scer\GAL4^elav-C155

(Palumbo et al., 2020)

lethal - all die before end of larval stage, with Scer\GAL4^elav-C155

(Palumbo et al., 2020)

lethal - all die during embryonic stage | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

(Palumbo et al., 2020)

Phenotype Manifest In

centrosome | embryonic stage | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

(Palumbo et al., 2020)

chromatin | embryonic stage | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

(Palumbo et al., 2020)

larval brain | larval stage, with Scer\GAL4^elav-C155

(Palumbo et al., 2020)

mitotic spindle | embryonic stage | maternal effect, with Scer\GAL4^{VP16.mat.αTub67C}

(Palumbo et al., 2020)

Detailed Description

Statement

Reference

Expression of mora^HMC06216 under the control of Scer\GAL4^elav-C155 leads to mitotic defects in larval brains when compared to controls.

Expression of mora^HMC06216 under the control of Scer\GAL4^{VP16.mat.αTub67C} leads to defects in chromatin condensation, mitotic spindle morphology and centrosome amplification in embryos when compared to controls.

(Palumbo et al., 2020)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

66324

y¹ sc^* v¹ sev²¹; P{TRiP.HMC06216}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CHORD^HMC06216

mora^HMC06216

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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