FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\BNIP3UAS.Tag:HA
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General Information
Symbol
Hsap\BNIP3UAS.Tag:HA
Species
H. sapiens
Name
FlyBase ID
FBal0325122
Feature type
allele
Associated gene
Hsap\BNIP3
Associated Insertion(s)
Carried in Construct
P{UAS-hBNIP3.HA}
Key Links
Transgenic product class
cDNA
(Zhang et al., 2016)
wild_type
(Zhang et al., 2016)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Zhang et al., 2016)
wild_type
(Zhang et al., 2016)
Mutagen
in vitro construct
(Zhang et al., 2016)
Progenitor genotype
Carried in construct
P{UAS-hBNIP3.HA}
Cytology
Description

UASt regulatory sequences drive expression of Hsap\BNIP3 cDNA, with a C-terminal Tag:HA tag.

(Zhang et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\BNIP3
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease
      modeled by Pink1B9
      (Zhang et al., 2016)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The constitutive expression of Hsap\BNIP3Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4da.PU induces lethality.

      The expression of Hsap\BNIP3Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Mhc.PU leads to no obvious defects in either adult locomotion (assessed by negative geotaxis assays), wing posture, thorax morphology, or in the mitochondria of indirect flight muscles and of thorax, as compared to controls; expression under the control of Scer\GAL4ple.PU also leads to no obvious defects in mitochondria in adult dendritic arborizing neurons, as compared to controls.

      (Zhang et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The expression of Hsap\BNIP3Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4Mhc.PU fully suppresses the adult locomotive defects, the wing posture defects, the thorax morphology defects and the mitochondrial aggregation defects in both indirect flight muscles and thorax exhibited by Pink1B9 homozygous adults; expression under the control of Scer\GAL4ple.PU also fully suppresses the mitochondria aggregation defects present in dendritic arborization neurons of Pink1B9 homozygous adults.

      (Zhang et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\BNIP3Scer\UAS.T:Ivir\HA1
      Hsap\BNIP3UAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (2)