FB2026_02 , released June 18, 2026
Allele: Dmel\trpD621N
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General Information
Symbol
Dmel\trpD621N
Species
D. melanogaster
Name
FlyBase ID
FBal0326656
Feature type
allele
Associated gene
Dmel\trp
Associated Insertion(s)
Carried in Construct
P{trp.D621N}
Key Links
Transgenic product class
missense_variant
(Liu et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Liu et al., 2007)
Mutagen
in vitro construct
(Liu et al., 2007)
Progenitor genotype
trp+t6.4
(Liu et al., 2007)
Carried in construct
P{trp.D621N}
Cytology
Description

6480bp genomic fragment containing trp that has been mutated to carry the amino acid replacement D621N.

(Liu et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
trp
Encoded product / tool
trp
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Flies expressing trpD621N in the trp9;trpl302 double mutant background show significant changes in their photoreceptor ionic selectivity profile (decreased permeability for both Ca[2+] and Mg[2+]), as well as decreased single channel conductance, alleviated channel block by Mg[2+] and ruthenium red and much slower kinetics of the light response and strongly increased rate of light-induced retinal degeneration (with most rhabdomeres entirely absent or exhibiting extensive signs of disruption of the microvillar structure, the cell bodies also contained multivesicular bodies) compared to controls.

      (Liu et al., 2007)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      trpD621N
      (Liu et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)