FB2026_03 , released September 17, 2026
Allele: Dmel\trpS936D.ninaE
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General Information
Symbol
Dmel\trpS936D.ninaE
Species
D. melanogaster
Name
FlyBase ID
FBal0326772
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
P[rh1-trpS936D]
Key Links
Nature of the Allele
Progenitor genotype
Carried in construct
Cytology
Description

A minimal ninaE promoter (-833 to +67) drives expression of trp carrying the amino acid replacement S936D (phosphomimetic mutation). ninaE 3'UTR sequences are also present.

Allele components
Component
Use(s)
Regulatory region(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Like wild-type, trp9 heterozygous flies carrying trpS936D.ninaE do not display oscillating voltage electroretinogram (ERG) response upon constant light stimulation. The electroretinogram response of light-adapted trp9/+;trpS936D.ninaE flies to oscillating light of gradually increasing frequencies is comparable to controls at lower stimulus frequencies, but mean oscillation amplitude of the response drops significantly at higher frequencies relative to controls. Dark-adapted flies show no significant changes in the onset of the frequency-locked response to oscillating light of either low (10Hz) or high (70Hz) frequency compared to wild-type flies. However, there is no difference in the timing of the onset of frequency-locked response between dark-adapted and light-adapted flies as both take about 8s to show response (similar to the onset time of dark-adapted controls), whereas in light-adapted wild-type flies it takes less than 0.3s until they display frequency-locked response.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
trpS936D.ninaE
Name Synonyms
Secondary FlyBase IDs
    References (2)