FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\PRODHUAS.cZa
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General Information
Symbol
Hsap\PRODHUAS.cZa
Species
H. sapiens
Name
Saccharomyces cerevisiae UAS construct a of Zwarts
FlyBase ID
FBal0327339
Feature type
allele
Associated gene
Hsap\PRODH
Associated Insertion(s)
Carried in Construct
P{UAS-hPRODH.Z}
Key Links
Transgenic product class
cDNA
(Zwarts et al., 2017)
wild_type
(Zwarts et al., 2017)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Zwarts et al., 2017)
wild_type
(Zwarts et al., 2017)
Mutagen
in vitro construct
(Zwarts et al., 2017)
Progenitor genotype
Carried in construct
P{UAS-hPRODH.Z}
Cytology
Description

UAS regulatory sequences drive expression Hsap\PRODH cDNA (Image clone 40108133) and a Kozak sequence.

(Zwarts et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\PRODH
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  schizophrenia
      CEA
      (Zwarts et al., 2017)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\PRODHUAS.cZa under the control of either Scer\GAL4P2.4.Pdf or Scer\GAL4cry.PE, but not when under the control of Scer\GAL4ey-OK107 or Scer\GAL4Tab2-201Y, leads to a significant increase in aggressive behavior, compared to controls; Scer\GAL4P2.4.Pdf-driven expression does not significantly affect overall locomotion (walking behavior), circadian rhythmicity or sleep (under either LD cycles or constant darkness), or resistance to starvation. s-LNv neurons show an increase in the size, but not in the number, of mitochondria.

      (Zwarts et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Hsap\PRODHScer\UAS.cZa
      Hsap\PRODHUAS.cZa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Zwarts
      Secondary FlyBase IDs
        References (1)